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Scientist Position for Natural Product Discovery at SpheroBiotics

SpheroBiotics discover novel compounds from microbial communities and develop medical drugs against multi-resistant pathogens. We are a startup from ETH Zürich, located at the Department of Biosystems Science and Engineering (D-BSSE) at ETH in Basel. We are looking for a talented, creative, and driven candidate to join our growing team and help us to harness the therapeutic potential of nature’s microbiota.

Scientist, Natural Product Discovery (60%-80%)

Microbiology • Antimicrobial Testing • Fermentation • Product Characterization

Your responsibilities include:

1) Effective contribution to SpheroBiotics’ efforts to discover, isolate and characterize novel classes of antimicrobials

2) Design and conduct high-throughput screening campaigns and secondary assays

3) DNA isolation, metagenomic and whole-genome sequencing

4) MIC assays using lab automation

5) Develop and execute plans for cultivation and product fermentation with non-laboratory strains

6) Develop and execute plans for small scale natural product purification

7) Assist with the design of streamlined drug identification and de-replication strategies

8) HPLC, MS/MS; (NMR optional)

9) Chemical structure database query

10) Biosynthetic gene cluster analysis (optional)

Requirements:

1) PhD in natural product research or at least 2 years of relevant industry experience

2) Microbiology techniques (bacteria and fungi)

3) Experienced in next-generation sequencing techniques

4) Experience with flow cytometry and/or microfluidics

5) Extensive knowledge of natural product fermentation, purification, and identification

6) Good knowledge in transfer of pilot fermentation to intermediate scale

7) Experience in the antibiotic discovery sector a plus

8) Highly motivated, solution-oriented, and a good team player

9) Excited about mastering unforeseen challenges, meticulous, analytical, inventive, and reliable

10) Must be eligible to work in Switzerland

Apply:

If you are excited to contribute meaningfully to SpheroBiotics, we invite you to send your CV, a motivation letter and a reference letter to [email protected]

Date : August 31, 2020

Location : Switzerland, Basel

APPLY HERE

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