SpheroBiotics discover novel compounds from microbial communities and develop medical drugs against multi-resistant pathogens. We are a startup from ETH Zürich, located at the Department of Biosystems Science and Engineering (D-BSSE) at ETH in Basel. We are looking for a talented, creative, and driven candidate to join our growing team and help us to harness the therapeutic potential of nature’s microbiota.
Scientist, Natural Product Discovery (60%-80%)
Microbiology • Antimicrobial Testing • Fermentation • Product Characterization
Your responsibilities include:
1) Effective contribution to SpheroBiotics’ efforts to discover, isolate and characterize novel classes of antimicrobials
2) Design and conduct high-throughput screening campaigns and secondary assays
3) DNA isolation, metagenomic and whole-genome sequencing
4) MIC assays using lab automation
5) Develop and execute plans for cultivation and product fermentation with non-laboratory strains
6) Develop and execute plans for small scale natural product purification
7) Assist with the design of streamlined drug identification and de-replication strategies
8) HPLC, MS/MS; (NMR optional)
9) Chemical structure database query
10) Biosynthetic gene cluster analysis (optional)
Requirements:
1) PhD in natural product research or at least 2 years of relevant industry experience
2) Microbiology techniques (bacteria and fungi)
3) Experienced in next-generation sequencing techniques
4) Experience with flow cytometry and/or microfluidics
5) Extensive knowledge of natural product fermentation, purification, and identification
6) Good knowledge in transfer of pilot fermentation to intermediate scale
7) Experience in the antibiotic discovery sector a plus
8) Highly motivated, solution-oriented, and a good team player
9) Excited about mastering unforeseen challenges, meticulous, analytical, inventive, and reliable
10) Must be eligible to work in Switzerland
Apply:
If you are excited to contribute meaningfully to SpheroBiotics, we invite you to send your CV, a motivation letter and a reference letter to [email protected]
Date : August 31, 2020
Location : Switzerland, Basel
